From Conventional to Targeted: Tracing the Pivotal Shift in Soft...

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2025-10-30 10:04:43 -

From Conventional to Targeted: Tracing the Pivotal Shift in Soft Tissue Sarcoma Treatment Modalities and Drug Pipeline Dynamics

Historically, the treatment paradigm for soft tissue sarcoma (STS) relied heavily on a combination of surgical resection, radiation therapy, and cytotoxic chemotherapy, the latter often serving as the primary systemic treatment for advanced or metastatic disease. While chemotherapy drugs like doxorubicin and ifosfamide remain foundational, their non-specific mechanism of action often leads to...

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