Beyond Off-Target Effects: How Base Editing and Prime Editing are...

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2025-11-18 11:20:27 -

Beyond Off-Target Effects: How Base Editing and Prime Editing are Redefining Precision and Unlocking New Opportunities in the Gene Editing Market.

While CRISPR/Cas9 revolutionized molecular biology, its mechanism—creating a double-strand break (DSB) in the DNA—carries inherent risks, including potential off-target edits at unintended genomic locations and unpredictable repair outcomes that can lead to large deletions or translocations. This safety concern has been a major point of regulatory scrutiny and a limit to its broader...

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